Association of the asporin D14 allele with lumbar-disc degeneration in Asians.
نویسندگان
چکیده
Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.
منابع مشابه
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ورودعنوان ژورنال:
- American journal of human genetics
دوره 82 3 شماره
صفحات -
تاریخ انتشار 2008